The circadian rhythm is the body’s internal clock. It is the most important thing needed for physiological and behavioral functions. It is the natural 24-hour cycle that affects our sleep, wakefulness, hormone production, and metabolism. In the world of supplements, there are two Rev-ErbA agonists, like SR9009 and SR9011, that can fix this circadian rhythm. Unlike SARMs or peptides, these compounds target the body’s circadian rhythm and metabolic processes. Thus, they bring unique benefits such as fat loss, improved endurance, and enhanced energy regulation.
In this article, we will draw a comparison between these two compounds, SR9009 vs. SR9011. We will compare their mechanisms, benefits, side effects, and more.
What is SR9009 (Stenabolic)?
SR9009 is also known as Stenabolic. It is a synthetic Rev-ErbA agonist, originally designed to study the relationship between circadian rhythm, metabolism, and obesity.
Key Features of SR 9009:
- ➢ Mitochondrial activity increases in skeletal muscle
- ➢ Boosts fat oxidation and calorie expenditure
- ➢ Endurance and stamina increase
- ➢ Circadian rhythm (sleep-wake cycle) comes back to normal
- ➢ Mimics the effects of exercise and his hence called “exercise mimetic” compound
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What is SR9011?
SR9011 is another Rev-ErbA agonist. It is also closely related to SR 9009, but with some differences. Researchers call SR9011 a next-generation analog of SR9009. It is more stable and more potent.
Key Features of SR9011:
- ➢ Provides stronger and more consistent Rev-ErbA activation
- ➢ Burns fat and boosts metabolism
- ➢ Longer-lasting effects as compared to SR9009
- ➢ More stable in the bloodstream
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Mechanism of Action
SR9009 and SR9011 are Rev-ErbA agonists. Both affect the body’s circadian rhythm and metabolism. By activating Rev-ErbA receptors, they influence processes like glucose regulation, fat oxidation, and mitochondrial function.
| Compound | Mechanism of Action |
| SR9009 | Binds to Rev-ErbA receptors, increasing mitochondrial activity, enhancing endurance, and boosting fat metabolism. |
| SR9011 | Similar binding but with greater potency and stability, potentially leading to more pronounced metabolic effects. |
Benefits of SR9009 vs. SR9011
| Category | SR9009 (Stenabolic) | SR9011 |
| Fat Loss | Promotes calorie burning and fat oxidation | Similar effects, but may be stronger due to higher potency |
| Endurance | Known as an “exercise mimetic,” it boosts stamina | Comparable or slightly greater due to stronger receptor activity |
| Energy & Wakefulness | Helps regulate circadian rhythm and improve energy levels | Similar benefits, possibly longer-lasting |
| Glucose Regulation | May enhance glucose tolerance and insulin sensitivity | Comparable effects with potentially more stable outcomes |
| Mitochondrial Function | Increases mitochondrial activity in muscles | Similar but possibly stronger due to improved stability |
Side Effects and Safety Profile
Like with any dietary supplement, SR9009 and SR9011 can have potential side effects. Some potential side effects of both are:
- ➢ Circadian Rhythm Disruptions
- ➢ Headaches
- ➢ Liver Toxicity
- ➢ Hormonal Impact
- ➢ Sleep Disruption
- ➢ Nausea
- ➢ Anxiety
Which One Should I Choose?
- ➢ You should choose SR9009 (Stenabolic) if your goals are fat loss, enhanced endurance, and regulation of circadian rhythm in shorter cycles. It is easily available, so it is more commonly used.
- ➢ However, you should choose SR9011 if you want a stronger, more stable analog. It has a greater metabolic impact and more reliable results compared to SR9009.
Summary: SR9009 vs. SR9011
| Feature | SR9009 (Stenabolic) | SR9011 |
| Potency | High | Higher |
| Stability | Moderate | Stronger and longer-lasting |
| Fat-Burning | Effective | Potentially more effective |
| Endurance Boost | Significant | Comparable or slightly stronger |
| Availability | Widely available | Less common but growing in research use |
| Best For | Fat loss, endurance, and circadian rhythm studies | Advanced metabolic research with stronger results |
Frequently Asked Questions
Are SR9009 and SR9011 Legal?
The compounds are only legal to buy or sell for laboratory research use. The FDA and World Anti-Doping Agency have not given them a green signal as a supplement yet.
What is the recommended dosage for SR-9009 and SR9011?
To attain its optimum effects, a starting dose of 20mg per day with a cycle of 5mg every 4-5 hours is recommended. Remember that keeping the dosage lower will lessen the risk of side effects.
What is the Half-Life of SR-9009 and SR-9011?
Both have a relatively short half-life of 4 to 5 hours.
Where can I buy SR-9009 and SR-9011 online?
The quality of supplements can vary between brands. Select products from reputable manufacturers and consider consulting a healthcare professional for guidance on choosing a high-quality supplement.
