There is evidence that SARMs do suppress natural hormone levels and hormone production. Clinical studies on LGD show suppression at low doses, whilst anecdotal experience and published bloodwork from researchers on various forums and blogs iterate this point. Many researchers claim SARMs to be the holy grail of peds but, as with most things in life, every action has an opposite and equal reaction.

SARMs do not necessarily cause complete hormonal shutdown (as opposed to something like synthetic testosterone). It seems as if the HPTA-axis may recover after SARMs use. However, SERMs (selective estrogen receptor modulators) may be used on the cessation of a cycle to help hormone levels normalize. This is usually advised when more than one compound is stacked (eg. Rad140 and LGD4033).

Yes, SARMs do have side effects. These include hormone suppression, hair loss, fatigue and water retention, to name a few. SARMs are not side effect free. Refer to question 1, “Are SARMs safer than Steroids?”.

SARMs have not been cleared by the FDA for human use and are, at this stage in time, considered research chemicals intended for research purposes.

Many SARMs were created to help combat muscle-wasting diseases. This means that SARMs have the potential to sustain existing muscle and encourage muscle growth and strength gain.

Medical research has indicated that some compounds increased lean muscle mass and also increased endurance in participants of these studies.

There are many SARMs cycle logs available to read and study. Denying SARMs’ ability to cause muscle growth would be silly, however, it is important to note that these compounds were created as potential medical interventions for patients suffering muscle- and bone wasting. They are not intended to be supplements to an exercise routine.

Please read our “Sample SARMs Cycles” for more information regarding SARMs use and building muscle.