Confused about what your HRT dosage and cycle plan should look like? You are not alone. Many people resort to HRT solutions without fully understanding the dosage and cycles of it. Hormone Replacement Therapy (HRT) is the medical answer to the problem of hormonal imbalance. So, naturally, HRT’s effectiveness and safety will depend only on accurate dosing and proper cycle management. This article provides a guide for you so that you can have a proper chart for your dosage and HRT cycles.
Confused about what your HRT dosage and cycle plan should look like? You are not alone. Many people resort to HRT solutions without fully understanding the dosage and cycles of it. Hormone Replacement Therapy (HRT) is the medical answer to the problem of hormonal imbalance. So, naturally, HRT’s effectiveness and safety will depend only on accurate dosing and proper cycle management. This article provides a guide for you so that you can have a proper chart for your dosage and HRT cycles.
Hormones are the elements that control your body’s functions. They regulate metabolism, mood, strength, energy levels, and overall well-being. As we age, hormone production naturally declines. This leads to many physical and emotional symptoms. HRT aims to bring those hormone levels up to an optimum level. So basically, it’s not just restoration of hormones but also ensuring that they perform in harmony for better health and longevity.
There are two primary categories of HRT:
First-time SARM users tend to have a much lower tolerance and are advised to stick to a lower dosage. It is important to assess how the body responds to these powerful compounds. More experienced users are familiar with the potential effects and unwanted side effects. They are more familiar with how the body reacts and will be able to better monitor dosage and cycle length.
Because each SARM has different effects and properties, it’s key to find the right compound that suits your fitness goals. Ostarine is known for helping with cutting phases and muscle preservation, while a powerhouse like Ligandrol is known for bulking.
To make sure you achieve your fitness goals, make sure you are on the correct SARM cycle.
Gender is an interesting topic for debate when it comes to SARMs. Men tend to find SARMs appealing as it is a safer alternative to conventional anabolic steroids.
However, they are also quite popular amongst women seeking a muscle-building agent with less effects on hormone balance. Unlike most anabolic steroids, they do not cause a deeper voice and male-pattern hair growth.
Gender does in fact play a vital role in determining the dosage, risks, and effects associated with SARMs. Women should approach SARMs more cautiously as opposed to men. This typically means administering lower dosages to reduce and minimize the risk of androgenic side effects. Men can tolerate higher dosages with more pronounced effects.
Body weight can significantly influence the effectiveness of a SARM cycle. As with most compounds, body weight impacts how a SARM is metabolized, and the dosage needed for effective results. Individuals with a higher body weight may need an increased dosage to achieve results similar to those of someone with a lower body weight.
SARM potency directly affects the dosage and cycle length. More potent SARMs generally require smaller doses to achieve effective results as opposed to less potent SARMs. This is also applicable to the form of SARMs such as tablets or liquids. The oral bioavailability of a liquid tends to be much higher than that of a capsule or tablet. Liquids have faster absorption and are more efficiently absorbed into the bloodstream.
| Hormone | Typical Dosage | Frequency | Form | Cycle Duration | Remarks |
| Testosterone Cypionate/Enanthate | 100–200 mg | Weekly (1–2 injections) | Injectable | Continuous | Start at 100 mg/week. Adjust based on blood levels. |
| HCG (Human Chorionic Gonadotropin) | 250–500 IU | 2–3x weekly | Injectable | Alongside TRT | Helps preserve fertility and natural testosterone production. |
| Anastrozole (Aromatase Inhibitor) | 0.25–0.5 mg | 2x weekly | Oral | As needed | Controls estrogen conversion; monitor E2 levels. |
| DHEA (Dehydroepiandrosterone) | 25–50 mg | Daily | Oral | Continuous | Supports testosterone synthesis and energy levels. |
| GH Peptides such as Ipamorelin + CJC-1295) | 100–200 mcg each | 1–2x daily | Injectable (subQ) | 3–6 months | Promotes growth hormone release and lean muscle growth. |
| Pregnenolone | 25–50 mg | Daily | Oral | Continuous | Boosts mood and mental function. |
| Hormone | Typical Dosage | Frequency | Form | Cycle Duration | Remarks |
| Estradiol (E2) | 0.25–1 mg | Daily | Oral / Transdermal / Injectable | Continuous or cyclical | Used to relieve menopause symptoms and balance estrogen. |
| Progesterone (Micronized) | 100–200 mg | Nightly | Oral / Transdermal | 12–14 days/month (cyclic) or daily | Protects uterine lining and supports mood/sleep. |
| Testosterone (Low Dose) | 2.5–10 mg | Daily | Topical / Injectable | Continuous | Helps libido, energy, and muscle tone. |
| DHEA | 10–25 mg | Daily | Oral | Continuous | Enhances mood and balances estrogen/testosterone. |
| Thyroid Hormones (T3/T4) | Variable | Daily | Oral | Continuous | Balances metabolism and energy levels. |
| Melatonin / Peptides (GHRP-2, CJC-1295) | 100–200 mcg | 1–2x daily | Injectable (subQ) | 2–4 months | Supports sleep, recovery, and growth hormone production. |
Seeing the above symptom feedback, you should make adjustments.
Men’s TRT Sample Cycle (12 Weeks):
Women’s HRT Sample Cycle (8 Weeks):
A standard HRT cycle consists of three phases:
Maintenance Phase (Ongoing): Steady-state dosing with regular monitoring every 3–6 months.
| Peptide | Typical Dosage | Purpose |
| CJC-1295 + Ipamorelin | 100–200 mcg each 1–2x/day | Boosts GH production Improves sleep Recovery Body composition |
| BPC-157 | 250–500 mcg/day | Tissue and gut repair Anti-inflammatory |
| TB-500 (Thymosin Beta-4) | 2–5 mg/week | Accelerates recovery Healing |
| Epithalon | 10 mg/day for 10 days (quarterly) | Promotes longevity Regulates melatonin Cell regeneration |
| Kisspeptin-10 | 100 mcg 2–3x/week | Boosts natural gonadotropin release for fertility and testosterone |
HRT cycles should always be personalized. Expert medical supervision is a must, also. Overdosing or poor management can lead to side effects such as:
An effective HRT program is not a single package that can be sold to all. It is not a one-size-fits-all formula. A good effective program is a perfect balance of hormones needed for the individual. It’s a carefully balanced protocol. The balance depends on the user’s biochemistry, age, and health goals. With the correct dosages and cycles, consistent monitoring, and the right blend of peptides or supplements, HRT can restore vitality, muscle strength, sexual health, and cognitive clarity. HRT can make you live stronger and longer.
When starting or adjusting an HRT cycle, always go to the experts. Sarmcentral recommends PrometheuzHRT as one of the best places to go for HRT. They give you personalized hormone replacement therapy (HRT) to restore balance that improves overall wellbeing.
HRT is not like steroids. So you do not have to cycle off completely. Most individuals stay on continuous HRT. They do minor adjustments every 3–6 months based on labs and symptoms and they are good to go.
Yes. Peptides like CJC-1295, Ipamorelin, and BPC-157 work great with HRT. The results can boost recovery, growth hormone production, and tissue health.
Most users report noticeable improvements within 4–8 weeks. However, full benefits appear after 3–6 months of consistent use.
Only if estradiol levels rise excessively, overusing blockers is bad for joint pain, fatigue, and low libido
Yes, they can, but in very low doses. It can boost mood, libido, and energy when balanced with estrogen and progesterone.
Yes, HRT is safe as long as it is being monitored by a qualified provider. HRT must also come with clean nutrition, fitness, and periodic lab checks.
