IBUDILAST

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Overview

Ibudilast (MN-166) is an oral agent with novel immune modulating and potential neuroprotective properties that is being studied in progressive MS. This agent has also been studied in a range of conditions including chronic pain, headache, and in the treatment of methamphetamine-dependent addicts. Based on early MS trial evidence that ibudilast had a primary neuroprotective role independent from a substantial effect on overt inflammation, the Phase II Secondary and Primary Progressive MS Ibudilast NeuroNEXT trial (SPRINT-MS) 64 was launched in Fall 2013. It will include 28 enrolling clinical sites across the United States.

The trial is designed to evaluate the safety, tolerability, and efficacy of MN-166 (ibudilast) administered twice daily to individuals with primary- or secondary-progressive MS. Primary outcomes of this trial will be MRI findings, including brain atrophy, as this is felt to be an important aspect of progression in MS. There will also be several other imaging and clinical disability outcomes evaluated. The trial is expected to require approximately three years for enrollment, treatment, and data analyses, and will run through the end of 2016.

 



 

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Dosage

Note; dosage information is only for scientific reference purposes. SARMs Central, does not condone the human consumption or use of this substance outside of a controlled scientific environment (i.e. a lab).

The average dose for Ibudilast falls between 40-100 mg twice daily. Start at a moderate dosage to test your tolerance and gradually increase the dosage from there.

About Author

Calvin Ramos

Calvin Ramos is a dedicated research and fitness enthusiast with a passion for helping individuals achieve their health and wellness goals. With years of experience in the fitness industry and a deep commitment to staying up-to-date with the latest research and developments in the field, Calvin brings a wealth of knowledge and expertise to his articles. As a fitness coach and nutrition specialist, Calvin has helped countless clients transform their lives through personalized training programs and evidence-based dietary recommendations. He holds a Bachelor's degree in Exercise Science and Nutrition from University and is certified in personal training and sports nutrition. Calvin's writing reflects his commitment to providing accurate and trustworthy information to empower readers on their fitness journeys. He believes in the power of education and strives to make complex fitness concepts accessible to everyone. His articles are thoroughly researched, drawing on the latest scientific studies and expert insights. When he's not writing or coaching, you can find Calvin in the gym, experimenting with new workout routines, or exploring the latest advancements in fitness technology. His dedication to the field of fitness and wellness is evident in his articles, which aim to inspire and inform readers on their path to a healthier, happier life.

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