AICAR is an analog of AMP (adenosine monophosphate), which stimulates AMPK (AMP-dependent protein kinase) processes in the body. As a matter of fact, AICAR works best as part of an endurance stack, and it has been used by athletes as a performance enhancing compound in sports, where endurance is needed. AICAR has been used medically to help with restriction of blood supply to tissues, called ischemia. Interestingly, in the 1980’s it was sometimes used during surgery to help preserve blood flow to the heart. These days, AICAR shows to be promising in diabetes treatment because of its ability to increase metabolic activity of tissues by changing the composition of muscles in the body. AICAR will trigger AMP activated protein kinase (AMPK), leading to glucose uptake by cells of skeletal muscle. In fact, The Howard Hughes Medical Center and Salk Institute ran a series of experiments with AICAR in the 2000’s. In these studies they found out that mice that were given AICAR could run 44% further
, even without training for it. Consequently, once endurance athletes got word of this amazing compound, AICAR was being used without any regulation or fear of testing until 2011.
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Note; dosage information is only for scientific reference purposes. SARMs Central, does not condone the human consumption or use of this substance outside of a controlled scientific environment (i.e. a lab).
Dosages range from 150 milligrams (mg) per day (if stacked with GW), up to 500mg a day when used solo. Considering the fact that each bottle typically comes in 50mg dosages, that is quite expensive, as already mentioned above. Economically, it makes most sense to run AICAR during the 4 weeks leading up to your competition. Potential Side Effects
AICAR’s side effects are very real and serious. Since it affects blood flow, AICAR can cause less blood going to your brain and heart valve issues. Hence, those side effects make AICAR one of the most risky compounds to use in the PED world. Less significant side effects, such as diarhea and thirst, are also common.