SARMs have become the most desired off-the-shelf items and have recently gained immense popularity in the bodybuilding industry, especially after widely shared SARMs before and after results. While SARMs are already known for proven beneficial effects on muscle growth, lean body mass, increasing bone density, muscle and bone mass enhancement, and boosting physical performance, this article will specifically cover two of the most discussed SARMs Andarine (S-4) and Ostarine (MK-2866). While both work by selectively binding to androgen receptors in muscle and bone tissue, they differ in potency, side effects, and ideal use cases.
We will break this article down into its mechanisms, benefits, side effects, dosage guidelines, and key differences.
Overview of Andarine (S-4)
Chemical Name: S-4
Primary Purpose: Cutting
Potency: High as compared to other SARMs
Half-life: 4–6 hours
The S4 is a novel non-steroidal selective androgen receptor modulator (SARM). The drug has been investigated for the treatment of age-related cognitive decline. It has been shown to be as potent and efficacious as testosterone in vitro assays without interaction with other hormone receptors.
In addition, the S4 demonstrates to be one of those potent anabolic steroids which have beneficial effects on cutting fat and improving muscle and bone with minimal effect on the prostate. Andarine S4 belongs to the class of androgenic anabolic steroids made up of molecules referred to as selective androgen receptor modulators (SARMs).
Overview of Ostarine (MK-2866)
Chemical Name: Enobosarm
Primary Purpose: Lean muscle growth, recomposition, recovery
Potency: Moderate and beginner-friendly
Half-life: ~24 hours
Ostarine was created to help as a treatment for patients undergoing degenerative bone disorders. It was used for disorders such as arthritis and osteoporosis, and also breast cancer {R}. It was designed to offer a safer alternative to anabolic androgen steroids and prohormones. It binds to androgen receptors found in the bone tissue and also in the muscles.
Mechanism of Action
SARMs, in general, have this tendency to selectively bind to ARs (androgen receptors). The human body typically has 47 nuclear receptors. While other compounds in the market are generic in their targeting of tissues and body receptors, both MK-2866 and the S4 are very selective in their targeting of AR, hence making them a great option for people looking for faster muscle gain.
However:
- ➢ Andarine (S-4) has a stronger binding affinity. This makes it do wonders with respect to rapid changes in strength and body composition. At the same time, the risk of side effects with S4 is higher as compared to Ostarine.
- ➢ Ostarine (MK-2866) has a milder binding effect. That means slower results but a safer experience for beginners.
Benefits
Andarine S4 – Benefits
Out of the countless benefits of Andarine S4, some of the few that have been suggested in research and anecdotal reports include:
- ➢ Muscle Preservation {R}
- ➢ Increased Strength {R}.
- ➢ Fat Loss {R}
- ➢ Improved Endurance {R}
- ➢ Improved Bone Health and Bone Density {R}.
- ➢ Potential for Osteoporosis Treatment {R}.
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Ostarine MK 2866 – Benefits
This SARM has undoubtedly got it all. Its benefits include:
- ➢ Potential for Muscle Building and Overall Lean Body Mass
- ➢ Potential for Improved Recovery and Repair Time of Muscle Tissues
- ➢ Ostarine and Fat Loss
- ➢ Potential for a Composite Body Structure
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Benefits Comparison
| Benefit | Andarine (S-4) | Ostarine (MK-2866) |
| Muscle Growth | Moderate | Moderate |
| Strength Gains | High | Moderate |
| Fat Loss | High | Moderate |
| Muscle Preservation | Very High | High |
| Joint Healing | Low | High |
| Recomposition | High | High |
| Best For | Cutting | Bulking/Recomp |
Side Effects
Andarine
With the numerous benefits on offer, it is however, essential to note that the use of SARMs like Andarine S4 is for laboratory research use and as such not without risks. Potential side effects include: {R}
- ➢ Hormonal imbalances
- ➢ Vision changes (yellow tint, night blindness)
- ➢ Mild testosterone suppression
- ➢ Potential hair shedding
Ostarine (MK-2866):
Ostarine in any of its formations is safe when used responsibly. However, like any supplement, it can have some side effects. Some of them may include:
- ➢ Gastrointestinal Issues
- ➢ Headaches
- ➢ Dizziness
- ➢ Fatigue
- ➢ Insomnia
Important: Post Cycle Therapy (PCT) is recommended after both compounds, though Ostarine’s PCT may be milder.
Dosage Guidelines
Andarine (S-4):
The latest studies using dosages w.r.t body composition range from 3 to 10mg per kg body weight. If we look at the anecdotal experience, we will see that most users take a dosage between 25mg to 100mg per day.
There is no optimal dosage established for human consumption yet. However, most users would say an Andarine dosage of 50mg is optimal. Most users also experience vision side effects at this dosage.
A general cycle of Andarine would be 50mg split into 2 dosages for 8 weeks. A PCT for SARM would be highly advised because S4 has been shown to be suppressive.
We wouldn’t recommend going any higher than 100mg a day because of the vision side effects occurring rapidly at a higher dose. {R}
Ostarine (MK-2866):
Generally, based on average users, it is recommended that Ostarine be taken in a dose of 10-20 mg for 30 to 60 days.
Which Is Better for Your Goal?
There is no best solution for all problems. The better SARM among the two totally depends on what you are using it for. For specific purposes following is recommended as a better choice:
- ➢ For Cutting & Fat Loss:
Andarine wins. It is great for preserving lean tissue while burning fat. Makes it a cutting favorite.
- ➢ For Bulking & Recomposition:
Ostarine is the safer choice for lean mass gains, often featured in best SARMs for bulking guides. It achieves it without suppression or side effects.
- ➢ For Beginners:
Ostarine is more beginner-friendly. That’s because it has a mild profile and minimal side effects.
- ➢For Advanced Users:
Andarine is better suited for those with previous SARM experience. Pros can manage potential side effects better.
Stacking Potential
Some users experiment with a SARMs stack for cutting and bulking to combine benefits:
Andarine + Ostarine: Improves recomposition
- ➢ Ostarine supports lean gains while Andarine drives fat loss.
- ➢ Lower doses of both to reduce suppression risk.
Legal Status and Safety
Regulations regarding SARMs may vary by country, and their use for performance enhancement or bodybuilding purposes is often discouraged or prohibited in competitive sports.
The drugs are specified for research use for now, and further research is needed to fully understand their mechanisms and assess their safety and efficacy in humans. Moreover, the World Anti-Doping Agency and the FDA are yet to approve these drugs in sports, which is why comparisons like prohormones vs SARMs often come up in discussions.
Bottom Line:
Due to their ability to promote muscle growth and improve physical performance, both SARMs have gained popularity in the fitness and bodybuilding communities. Athletes and bodybuilders use them as alternatives to traditional steroids to achieve similar effects with potentially fewer side effects. While Andarine is stronger and better for cutting, it comes with its baggage of a higher risk of vision-related side effects. On the other hand, Ostarine is milder, better for beginners, and great for lean gains and recovery.
So, the right choice depends on your experience level, physique goals, and tolerance for side effects, and understanding how longSARMs stay in your system is equally important before starting a cycle. Always source from a reputable vendor and consider proper PCT to safeguard hormonal health.
Frequently Asked Questions
Does Ostarine Shut Down Testosterone Production?
Not at all, there were no statistically significant differences in free testosterone levels in Ostarine groups relative to placebo in all of the studies conducted.
Where to Buy S4 and MK-2866?
For sourcing, check a reputable guide on where to buy SARMs to ensure authenticity. PureRawz, Iron Mountain Labz, Behemoth Labz and RCDBio are the best places to buy Sarms for sale.
They provide reference materials with every product they sell. Each of their SARMS comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
Which is the stronger SARM?
Andarine (S-4) is generally stronger in terms of rapid strength gains and fat loss. However, Ostarine (MK-2866) is milder but more beginner-friendly.
Can you stack Andarine and Ostarine together?
Yes, in order to combine Ostarine’s lean muscle support with Andarine’s fat-burning and cutting effects, many users stack the two compounds.
Can women use Andarine or Ostarine?
Yes, but they should use them at lower doses. Ostarine is usually the safer first choice for women.
How soon can I expect to see results?
Andarine users can expect results within 1–2 weeks. Ostarine results are slower. They will be visible around weeks 3–4.
