The circadian rhythm and metabolism are important physiological processes that help maintain health. The interplay between these two systems is intricate, and disruptions in their functioning can have significant implications for various aspects of health. SR-9011 is a synthetic Rev-Erb agonist studied for its potential effects on circadian rhythm, metabolism, and physical performance.
Similarity with SR-9009:
SR-9011 is closely related to SR-9009, another Rev-Erb agonist, and shares similar mechanisms.
How Does it Work?
- ➢SR-9011 works by binding to and activating Rev-Erbα, a nuclear receptor that regulates gene expression involved in various physiological processes, including circadian rhythm, metabolism, and inflammation. {R}
- ➢Once SR-9011 binds to Rev-Erbα, it modulates the activity of this nuclear receptor. Rev-Erbα functions as a nuclear receptor that represses transcription of specific target genes. The modulation of gene expression by SR-9011 affects pathways related to circadian rhythm regulation and metabolism. {R}
- ➢The circadian rhythm is the internal clock that regulates various biological processes in a 24-hour cycle. Rev-Erbα is a key player in this regulation. By modulating the activity of Rev-Erbα, SR 9011 may influence sleep-wake cycles and other circadian-regulated processes (preclinical evidence only). {R}
- ➢Research suggests that this circadian modulator can impact metabolism by influencing the expression of genes involved in glucose and lipid metabolism. This could have potential implications for conditions related to metabolic disorders, such as obesity and diabetes. {R}
- ➢The modulation of circadian rhythm and metabolism by SR-9011 has led to investigations into its potential therapeutic applications. Researchers are exploring its effects on conditions such as metabolic disorders, neurodegenerative diseases, and even certain types of cancer. {R}
SR-9011 Benefits
Here are some potential benefits associated with SR-9011 based on existing studies:
- ➢SR9011 interacts with the Rev-Erbα protein, a key regulator of the circadian rhythm. By modulating the activity of Rev-Erbα, SR-9011 may contribute to the regulation of the body’s internal clock. This could lead to improved sleep-wake cycles and overall circadian rhythm health. {R}
- ➢Studies suggest that SR9011 may influence the expression of genes involved in glucose and lipid metabolism. This could have potential implications for metabolic disorders, such as obesity and diabetes. By promoting a healthier metabolic profile, it may influence glucose and lipid metabolism in preclinical studies. {R}
- ➢Improved endurance was observed in animal studies, though human effects are unknown. By influencing the circadian rhythm and metabolism, the compound may contribute to increased energy levels in the skeletal muscle and improved exercise capacity. This potential benefit could be of interest to athletes and individuals engaged in regular physical activities. {R}
- ➢In mice treated with SR9011, it was also demonstrated that the circadian pattern of expression of many metabolic genes in the liver, skeletal muscle, and adipose tissue was changed, leading to an increase in locomotor activity and energy consumption. {R}
- ➢Increased endurance may reduce fatigue, which could be beneficial in demanding physical activities. {R}
- ➢Its role in circadian regulation has led researchers to explore possible cognitive effects, though evidence is limited.
- ➢To find out whether SR 9011 could have an impact on the immune response and cell metabolism of the immune cells in the brain, a dose-response study on the cell cycle was recently carried out. According to the study’s findings, this research molecule may be used as a potential target to treat neuroinflammation, metabolic disorders, neurodegeneration, and cancer research. {R}
- ➢Because cancer cells rely on altered metabolic states, restoring circadian regulation has been proposed as a possible therapeutic strategy. {R}
SR-9011 Side Effects
SR9011 may also carry potential side effects. Some side effects that have been reported are:
- ➢Disrupting the natural circadian rhythm could potentially lead to adverse effects on sleep patterns, alertness, and overall well-being.
- ➢Since SR-9011 has been associated with metabolic effects, there is a possibility of unintended consequences on metabolic processes. This may pose risks for individuals with pre-existing metabolic disorders.
Recommended Dosage of SR9011
To attain its optimum effects, a starting dose of 10 mg per day is recommended.
Where can I buy SR-9011 Online?
The quality of SR-9011 supplements can vary between brands. Choose products from reputable manufacturers, and consider consulting with a healthcare professional for guidance on selecting a high-quality SARMs. We recommend PureRawz, BehemothLabz, and RCDBio is the best place to buy SR 9011. While Behemoth Labz provides SR-9011 both in capsule and liquid forms, RCD Bio has the compound available in liquid form only. PureRawz provides SR 9011 in stack form to their online customers. To be the best suppliers of research chemicals, both online stores provide reference materials with every product they sell.
FAQs
Is It Legal?
SR-9011 is not approved for human use and is only legal for research purposes. It has no FDA approval as a supplement or drug.
What is the Half-Life of SR-9011?
Preclinical studies suggest SR-9011 has a short half-life (~4 hours), but human pharmacokinetics are unknown.
