Tirzepatide is making waves in the field of metabolic health. It is a GIP/GLP-1 receptor agonist that is being used as a medication for adults with obesity and diabetes. In this blog, we will discuss more about its mechanism, side effects, and how it will help with chronic obesity.
What is Tirzepatide?
Tirzepatide is a groundbreaking peptide that is being used as a prescription for obesity or overweight. It activates GIP receptors and GLP-1 receptors. As GIP/GLP-1 receptors, it enhances insulin production and controls blood sugar levels.
It is FDA-approved and is sold under the brand names Mounjaro and Zepbound. Mounjaro is used for diabetes treatment while Zepbound is for obstructive sleep apnea and chronic weight management.
Mechanism of Action
Tirzepatide has dual mechanisms – GIP receptors and GLP-1 receptors. As a gastric inhibitory polypeptide (GIP) receptor/glucose dependent insulinotropic polypeptide, it helps regulate insulin secretion and appetite.
While as a Glucagon-like peptide 1(GLP-1), it regulates meal-related glycemic fluctuations by increasing insulin and inhibiting the secretion of glucagon. GLP-1 also reduces the emptying of the stomach and food intake.
This mechanism increases the absorption of nutrients while reducing weight gain.
Benefits of Tirzepatide
Tirzepatide provides numerous benefits that are backed by research:
Weight Management
It is a clinically proven weight management solution. Studies show that it helps with weight reduction on obese patients. According to clinical trials, patients using it lose more weight compared to patients on placebo. This peptide controls the appetite by reducing hunger signals. In this way, patients can adhere to a lower-calorie diet.
Blood Sugar Control
This peptide reduces HbA1c levels significantly. It means it enhances glycemic control in type 2 diabetes patients. It also outperformed other medicines like insulin and other diabetes medications in maintaining lower blood sugar levels.
Cardiovascular Disease
It improves cardiometabolic risk factors like waist circumference, blood pressure and lipid levels. It also lowers the possibility of worsening heart failure in obese adults.
How to Administer Tirzepatide
Tirzepatide comes in three forms: injection, nasal spray, and sublingual tablets. Here we will learn how to properly do drug administration.
Tirzepatide Injection
Check the peptide’s vial label to double-check the expiration date and dosage. Make sure it’s not cloudy, frozen, or slightly yellow. Pull off the cap, wipe the rubber with the alcohol. Remove the needle shield and hold the syringe in one hand with the needle pointing up. Push the needle through the vial, turn the vial and needle upside down, and push to get the right dosage. Choose your injection site (thigh, belly or arms), push down the plunger to inject your dose, and pull the syringe out. That’s it.
Nasal Spray
Blow your nose to clear it from mucus. Shake the bottle to mix the medication. Sit upright, head should be slightly tilted forward. Insert the nozzle and place the tip into one nostril. Press down on the canister, while slowly breathing through your nose. Repeat steps with your other nostril.
Sublingual Tablets
Dissolve the tablet under your tongue. It should not be chewed or swallowed. Do not eat, smoke, or drink while dissolving the sublingual tablet.
How to Use Tirzepatide Safely
Always follow the prescribed dosage and dosing schedule. Start with the initial lower dose and increase gradually. Regularly check your blood sugar, weight, and other symptoms. Avoid mixing it with other medicines like metformin. For best results, combine it with a balanced diet and exercise.
Recommended Dosage of Tirzepatide
The recommended dosage depends upon the dosage forms and body weight of the patient. Seek medical advice to have the correct dosage. The typical starting dosage for weight loss and sleep apnea is 2.5 mg injected once a week for 4 weeks. The next dose will slowly increase based on the advice of your healthcare provider. 
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Potential Side Effects of Tirzepatide
Just like other medications, Tirzepatide also has possible side effects including:
- ➢ Nausea
- ➢ Decreased appetite
- ➢ Heartburn
- ➢ Diarrhea
- ➢ Hypoglycemia
- ➢ Constipation
- ➢ Allergic reactions
- ➢ Injection site reactions
Warnings and Precautions
Tirzepatide may interact with other drugs, any type of birth control pills, and dietary supplements. It is best to use it cautiously. It is not recommended for individuals with multiple endocrine neoplasia syndrome type 2 or those who will undergo other procedures like anesthesia or deep sedation.
Tirzepatide in Scientific Research
- ➢ Obese patients have an average weight reduction of 20.9% in over 72 weeks based on Surmount 1 trial.
- ➢ It proved to have a superior weight loss compared to insulin degludec according to Surpass Trials.
- ➢ There are also 38% reduction in major cardiovascular events based on Surpass Trials as well.
- ➢ For future studies, researchers are exploring Tirzepatide for hormonal disorders.
Tirzepatide vs Other Peptides
- ➢ It activates both the glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide receptors (GLP-1)
- ➢ Studies show greater reductions in HbA1c (long term blood sugar control) and body weight loss compared to Semaglutide.
- ➢ It has beneficial effects on cardiovascular risk factors.
Is Tirzepatide Legal?
Yes! Tirzepatide is legal in the USA. It is an FDA-approved medication for type 2 diabetes under the brand name, Mounjaru. Also, it has a brand name Zepbound, for chronic weight management.
Where to Buy Tirzepatide?
Since it is an FDA-approved medication to have low blood sugar and lose body weight, it is available in US pharmacies.
For easier access, buy online through your favorite peptide and SARM store like Behemothlabz. Their products have Certificates of Analysis and underwent third-party laboratory testing to ensure 98% purity.
Conclusion
Tirzepatide is transforming the landscape of obesity, cardiovascular diseases, and diabetes. Using FDA search will confirm its approval under the brand names Zepbound and Mounjaro. This active ingredient has a superior efficacy in blood sugar control, weight loss, and inflammation.
However, just like any medication, use it responsibly. Seek medical help if you experience adverse effects. As research progresses, this peptide will continue to push the boundaries of medical innovation.
Frequently Asked Questions (FAQs)
Will Tirzepatide make me sick?
The most common side effects are constipation, burping, diarrhea, hair loss, fatigue, abdominal pain, injection site reactions, vomiting, and nausea. Only 5% of the patients were affected.
Are Tirzepatide pills effective?
Tirzepatide is a medication approved by the US Food and Drug Administration (FDA). It demonstrates effectiveness in treating diabetes mellitus which could potentially avoid diabetic retinopathy and gastroparesis. It is also being used as a weight loss medication.
Can Tirzepatide cause hair loss?
Yes, only 5% of the patients population experienced this side effect.
Where to get Tirzepatide?
It is available in pharmacies but you need to present a prescription. You could also purchase it on online stores like Behemothlabz.
Are Tirzepatide and Semaglutide the same?
They are not the same. Tirzepatide is a dual agonist that acts as both GLP-1 and GIP receptors, while Semaglutide is only GLP-1 receptor. What does it mean? It can both control blood sugar and lose weight.
